Hyperthyroidism (Last Updated - 3/29/2005)

-induces a decrease in vit. K-dependent coag factors (Ex. II, VII, IX & X) --> pts. will have slightly prolonged PT's @ baseline
-because of above hyperthyroidism has additive effex when pts. are given Warfarin (Coumadin)

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References:

Goodman & Gilman's: The Pharmacologic Basis Of Therapeutics - 10th Edition - 2001. Chapter 55.